PROHLÍŽENÍ ABSTRAKTA

SUMMARY OF THE TRADITIONAL RISK FACTORS IN CZECH MALES SUFFERING ON ACUTE CORONARY SYNDROME – CHOLESTEROL RETREAT FROM THE FAME. Tématický okruh: Akutní koronární syndromy
Typ: Poster - lékařský , Číslo v programu: 244


Hubáček J.¹, Gebauerová M.¹, Staněk V.², Adámková V.³, Lánská V.¹, Piťha J.⁴ ¹ PEM, Laboratoř molekulární genetiky, IKEM, Prague, ² IKEM, Prague, ³ PPK, IKEM, Prague, ⁴ IKEM, Praha
Aim: Cardiovascular diseases are the most common cause of the mortality and morbidity around the world and the Czech Republic is not an exception. As the traditional risk factors (obesity, hypertension, dyslipidemia, diabetes, and smoking) were defined decades ago, we have performed an observational study to obtain data from the recent patient suffering acute coronary syndrome. Methods: Within the 7 years we have collected data from all together 999 males, younger than 65 years and suffering on the first acute coronary syndrome and compared them with the data from the Czech post –MONICA study (1,259 males). Results: We have detected that the most serious ACS risk factor is smoking (OR, 95%CI; 3.85, 3.12 – 4.73), followed by diabetes (2.26, 1.76 – 2.91), and hypertension (1.43, 1.21 – 1.69). There were no differences in the mean BMI values and plasma cholesterol was even significantly lower (P < 0.001) in the patients (4.80 ±1.11 mmol/L) in comparison with the controls (5.76 ± 1.06 mmol/L) even after exclusion of the patients on dyslipidemic treatment. Conclusions: There is significant shift of the prevalence of the traditional risk factors in Czech males. Plasma cholesterol seems not to be of major importance and the most serious ACS risk factor is smoking. Supported by MH, CR - conceptual development of research organization (IKEM, IN 00023001“)