PULMONARY HYPERTENSION AND RIGHT VENTRICULAR-PULMONARY ARTERIAL COUPLING IN CHRONIC HEMODIALYSIS POPULATION
Topic: Pulmonary hypertension | |
| Type: Presentation - doctors , Number in the programme: 68 | |
| Enlisted in: Young investigator awards | |
| Burýšková Salajová K.1, Malík J.1, Valeriánová A.1 1 III. interní klinika - klinika endokrinologie a metabolismu VFN a 1. LF UK, Všeobecná fakultní nemocnice v Praze, Prague | |
Aims: 1. To analyze the relations of PH and RV-PA coupling with arteriovenous fistula (AVF) flow and current hydration Methods: Inclusion visits of the patients included in CZecking Heart Failure in patients with advanced Chronic Kidney Disease study were analyzed. We performed expert echocardiography with non-invasive hemodynamic assessment, evaluation of AVF flow, bio-impedance analysis (BIA) and basic laboratory tests. The presence of PH was defined by the estimated pulmonary arterial systolic pressure >35 mmHg or by indirect signs of PH. RV-PA coupling was calculated as TAPSE/PASP, with values Results: Data of 336 patients were analyzed. PH was present in 34 % of patients, RV-PA uncoupling was present in 25 % of patients with PH and in 2 % of those without PH. PH and RV-PA uncoupling were related to higher hydration status. The association of AVF flow and the diagnosis of PH was weak (OR 1.27, CI 1.10-1.46), and RV-PA coupling was not dependent on AVF flow. Patients with RV-PA uncoupling had worse function and greater dilation of both ventricles compared to those with RV-PA coupling (Table 1.). In patients with PH, there was significantly higher prevalence of heart failure (HF) (79 % v.s. 37.5 %, p<.0001). Conclusions: 1. The relation between AVF flow and PH is weak. RV-PA coupling is not dependent on AVF flow. Both PH and RV-PA uncoupling are related to current hydration status | |
