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ACUTE SEVERE HEART FAILURE IMMEDIATELY REDUCES HEART RATE VARIABILITY: AN EXPERIMENTAL STUDY IN PORCINE MODEL.
Topic: field
Type: Presentation - doctors , Number in the programme: 13
Etický kodex:
Podpora výzkumu / granty: This work was supported by the Ministry of Health, Czech Republic, conceptual development of research organization (NHH, 00023884): IG180502, IG200505.
Naar J.1, Mlček M.2, Krüger A.1, Vondráková D.3, Janotka M.1, Popková M.2, Kittnar O.2, Neužil P.1, Ošťádal P.3

1 Kardiologické oddělení, Nemocnice Na Homolce, Prague, 2 Department of Physiology, First Faculty of Medicine, Charles University, Praha, 3 Kardiologická klinika, Fakultní nemocnice v Motole, Praha 5


Background: There are substantial differences in autonomic nervous system activation among heart failure (HF) patients and immediate effect of acute HF on autonomic function is not fully understood.
Objective: The aim our study was to assess the effect of experimental acute HF on heart rate variability (HRV).
Materials and methods: Twenty-four female swine of mean body weight 45 kg were used. Acute severe HF was induced by global myocardial hypoxia. In each subject, two 5-minute electrocardiogram segments were analyzed and compared: before the induction of myocardial hypoxia and > 60 min after the development of severe HF. HRV was assessed by time-domain, frequency-domain and nonlinear analytic methods.
Results: Induction of acute HF led to significant decrease in cardiac output, left ventricular ejection fraction and rise in heart rate. Development of acute HF was associated with a significant reduction of standard deviation of intervals between normal beats (50.8 [20.5 – 88.1] ms vs. 5.9 [2.4 – 11.7] ms, p < 0.0001) - figure 1. Highly significant a uniform reduction of HRV was observed also in other time-domain and main nonlinear analytic methods. Similarly, frequency-domain HRV parameters were significantly changed.
Conclusion: Acute severe HF induces an immediate reduction in HRV.