českyenglish

General partners

Pfizer_(2021)_300px_bez_okraje.png

Chiesi-logo_web.png

VIEW AN ABSTRACT

STRESS PULMONARY CIRCULATION PARAMETERS IN PATIENTS AFTER A HEART TRANSPLANT AND CANCER SURVIVORS: A CARDIOVASCULAR MAGNETIC RESONANCE STUDY
Topic: field
Type: Presentation - doctors , Number in the programme: 18
Etický kodex:
Podpora výzkumu / granty: The work was supported by the European Regional Development Fund - project ENOCH (No. CZ.02.1.01/0.0/0.0/16_019/0000868) and by the project "Novel imaging, computing and analytical methods in cardiovascular diseases diagnostics and monitoring" number MUNI/A/1462/2021 with the support of the Specific University Research Grant, as provided by the Ministry of Education, Youth and Sports of the Czech Republic in the year 2022.
Opatřil L.1, Panovský R.1, Mojica-Pisciotti M.2, Máchal J.3, Krejčí J.4, Holeček T.5, Feitová V.5, Kincl V.1, Kepák T.6, Špinarová L.7

1 I. interní kardioangiologická klinika, Mezinárodní centrum klinického výzkumu, FN U sv. Anny, Fakultní nemocnice u sv. Anny v Brně, Brno, 2 FN U sv. Anny, Mezinárodní centrum klinického výzkumu, Brno, 3 Ústav patologické fyziologie, Mezinárodní centrum klinického výzkumu, Lékařská fakulta Masarykovy univerzity, FN U sv. Anny, Brno, 4 I. interní kardioangiologická klinika, FN U sv. Anny, Lékařská fakulta Masarykovy univerzity, 5 Klinika zobrazovacích metod, Mezinárodní centrum klinického výzkumu, FN U sv. Anny, Brno, 6 FNB, FN U sv. Anny, Masarykova Univerzita, Klinika dětské onkologie, Lékařská fakulta Masarykovy univerzity, Mezinárodní centrum klinického výzkumu, Brno, 7 I. interní kardioangiologická klinika FN U sv. Anny, Lékařská fakulta Masarykovy univerzity, Brno


Background
Pulmonary circulation parameters such as pulmonary transit time (PTT), heart rate corrected PTT (PTTc) and pulmonary transit beats (PTB) can be evaluated using several methods, including the first-pass perfusion from cardiovascular magnetic resonance. Up to 58% of patients after HTx have diastolic dysfunction detectable only in stress conditions. By using adenosine stress perfusion images, stress analogues of the mentioned parameters can be assessed. By dividing stress to rest biomarkers, potential new ratio parameters (PTT ratio and PTTc ratio) can be obtained.
The objectives were to provide more evidence about stress pulmonary circulation biomarkers, present stress to rest ratio parameters, and assess these biomarkers in patients with presumed diastolic dysfunction after heart transplant (HTx) and in childhood cancer survivors (CCS) without any signs of diastolic dysfunction.
Methods
In this retrospective study, 48 patients after HTx, divided into subgroups based on echocardiographic signs of diastolic dysfunction (41 without, 7 with) and 39 CCS were enrolled.
Results
PTT in rest conditions were without significant differences when comparing the CCS and HTx subgroup without diastolic dysfunction (4.96 ± 0.93 s vs. 5.51 ± 1.14 s, p = 0.063) or with diastolic dysfunction (4.96 ± 0.93 s vs. 6.04 ± 1.13 s, p = 0.13). However, in stress conditions, both PTT and PTTc were significantly lower in the CCS group than in the HTx subgroups, (PTT: 3.76 ± 0.78 s vs. 4.82 ± 1.03 s, p <0.001; 5.52 ± 1.56 s, p = 0.002). PTT ratio and PTTc ratio were below 1 in all groups.
Conclusions
Stress pulmonary circulation parameters obtained from CMR showed prolonged PTT and PTTc in HTx groups compared to CCS, which corresponds with the presumption of underlying diastolic dysfunction. The ratio parameters were less than 1.