AN ASSOCIATION OF BIOMARKERS OF CARDIAC REMODELING, MYOCARDIAL FIBROSIS AND INFLAMMATION WITH THE PARAMETERS OF HEART FUNCTION AND STRUCTURE IN THE PATIENTS WITH ARTERIAL HYPERTENSION | Czech Cardiovascular Research and Innovation Days 2024

Backround: An early evaluation of the cardiac remodeling may be usefull in the prediction of heart failure development in the patients with arterial hypertension.
Study objective: to evalute the association of cardiac biomarkers levels with the parameters of cardiac structure and function in the patients with arterial hypertension.
Patients and methods: Patients with arterial hypertension with normal left ventricular ejection fraction (LV EF) and absence of signs of heart failure were included in the study. The levels of biomarkers: NT-proBNP, sST2, Galectin-3, GDF-15, Cystatin C, TIMP-1 and ceruloplasmin were measured and assessed together with other biochemical and echocardiographic parameters.
Results: Total number of 92 patients (61 % men) with mean age 61.5 years were included in the study. Mean LV EF was 64.7 % and mean LV mass index was 91.7 g/m2.
NT-proBNP level correlated significantly with the parameters of LV diastolic function: velocity of E wave (r = 0.377, p < 0.002), and with E/A ratio, (r = 0.455, p < 0.0001), with E lat (r = -0.354, p = 0.006), E/E´ ratio, r = 0.393, p < 0.002, with ePAP (r = 0.390, p = 0.014), and with age (r = 0,384, p < 0.0001).
In comparison of patients with and without left ventricular hypertrophy, statistically significant differences were found only in LA (p < 0.0001) and sST2 (p = 0.004).
In a multivariate logistic regression, sST2 and TIMP were independent predictors of left ventricular hypertrophy.

Conclusion: NT-proBNP level as a biomarker of cardiac remodeling correlates in the patients with arterial hypertension with the parameters of LV diastolic function. Soluble ST2 correlates with parameters of cardiac structure. Biomarkers sST2 and TIMP-1 are associated with left ventricular hypertrophy.

AN ASSOCIATION OF BIOMARKERS OF CARDIAC REMODELING, MYOCARDIAL FIBROSIS AND INFLAMMATION WITH THE PARAMETERS OF HEART FUNCTION AND STRUCTURE IN THE PATIENTS WITH ARTERIAL HYPERTENSION Topic: Hypertension, Atherosclerosis
Type: Presentation - doctors , Number in the programme: 24


Málek F.¹, Andreasová T.², Zákostelská-Jirásková Z.³, Neužil P.⁴, Vránová J.⁵ ¹ Kardiologické oddělení, Nemocnice Na Homolce, Praha, ² Third Faculty of Medicine, Charles University, Prague, ³ Laboratory of Cellular and Molecular Immunology Institute of Microbiology ASCR, ⁴ Kardiovaskulární centrum, Nemocnice Na Homolce, Prague, ⁵ 5. Department of Medical Biophysics and Medical Informatics, Third Faculty of Medicine, Charles University, Prague
Backround: An early evaluation of the cardiac remodeling may be usefull in the prediction of heart failure development in the patients with arterial hypertension. Study objective: to evalute the association of cardiac biomarkers levels with the parameters of cardiac structure and function in the patients with arterial hypertension. Patients and methods: Patients with arterial hypertension with normal left ventricular ejection fraction (LV EF) and absence of signs of heart failure were included in the study. The levels of biomarkers: NT-proBNP, sST2, Galectin-3, GDF-15, Cystatin C, TIMP-1 and ceruloplasmin were measured and assessed together with other biochemical and echocardiographic parameters. Results: Total number of 92 patients (61 % men) with mean age 61.5 years were included in the study. Mean LV EF was 64.7 % and mean LV mass index was 91.7 g/m2. NT-proBNP level correlated significantly with the parameters of LV diastolic function: velocity of E wave (r = 0.377, p < 0.002), and with E/A ratio, (r = 0.455, p < 0.0001), with E lat (r = -0.354, p = 0.006), E/E´ ratio, r = 0.393, p < 0.002, with ePAP (r = 0.390, p = 0.014), and with age (r = 0,384, p < 0.0001). In comparison of patients with and without left ventricular hypertrophy, statistically significant differences were found only in LA (p < 0.0001) and sST2 (p = 0.004). In a multivariate logistic regression, sST2 and TIMP were independent predictors of left ventricular hypertrophy. Conclusion: NT-proBNP level as a biomarker of cardiac remodeling correlates in the patients with arterial hypertension with the parameters of LV diastolic function. Soluble ST2 correlates with parameters of cardiac structure. Biomarkers sST2 and TIMP-1 are associated with left ventricular hypertrophy.

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