HOW INFERIOR VENA CAVA COLLAPSIBILITY INDEX FROM A NOVEL IMPLANTABLE SENSOR CORRELATES WITH ESTIMATED PLASMA VOLUME AND NT-PROBNP: A STUDY IN PATIENTS WITH CHRONIC HEART FAILURE
Topic: Heart failure | |
| Type: Presentation - doctors , Number in the programme: 8 | |
Etický kodex: Podpora výzkumu / granty: „Supported by Ministry of Health, Czech Republic - conceptual
development of research organization (Nemocnice Na Homolce – NNH,
00023884), IG190503
| |
| Málek F.1, Doškář P.1, Wetterling F.2, Marešová Z.1, Reddy V.3, Neužil P.4 1 Kardiologické oddělení, Nemocnice Na Homolce, Prague, 2 FIRE 1, Dublin, Ireland, 3 Heart Center, Mount Sinai Hospital, New York, United States, 4 Kardiovaskulární centrum, Nemocnice Na Homolce, Prague | |
Background:A new wireless implantable sensor can measure inferior vena cava (IVC) area and collapsibility index and was invented for remote monitoring in heart failure. Patients and methods: A novel sensor was implanted in six CHF participants of the First in Human Clinical Investigation of the FIRE1 System in Heart Failure Patients (FUTURE-HF) in our cardiac center. The collapsibility index of the IVC was recorded on each clinic follow-up visit. Patient´s weight was recorded and hemoglobin, hematocrit and NT-proBNP were analyzed from the blood samples. An estimated plasma volume (ePV) was calculated by the Tetsuko formula. The correlation of parameters was evaluated by Pearson´s correlation coefficient. Results: A total number of 58 measurments were analysed. The mean ePV was 7713.5 ml(median 7465 ml), the mean collapsibility index (CoI) was 46.5 % (median 42.2) and the mean NT-proBNP level was 1122.7 (median 988) ng/l. Statistically significant inverse correlation of collapsibility index (CoI) and estimated plasma volume was found (ePV and CoI, r = - 0.35, p = 0.0076). The correlation of NT-proBNP with CoI was not statistically significant (r = - 0.12, p = 0.31). It was expected that IVC CoI is accompanied by early volume increase and that its reduction preceeds rise in NT-proBNP – a sign that pronounced strain is exerted on the cardiac muscle. Conclusion: The collapsibility index of the inferior vena cava as assessed by a novel implantable sensor correlated with a biomarker of hemoconcentration, showing a statistically significant inverse correlation with plasma volume, and thus may provide a promising tool to evaluate volume status in heart failure patients in their homes. | |
