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filter of CSC event applied: nonefilter of Thematic fields applied: nonefilter 1st author applied: noneAplikovaný filtr Typ dat: neomezenoSILDENAFIL INHIBITS PULMONARY HYPERTENSION INDUCED BY LEFT HEART PRESSURE OVERLOAD IN RATS
Pulmonary hypertension (PH) induced by pressure overload of the left heart has recently attracted attention in clinical practice. No specific...
CATHETER ABLATION OF ATRIAL FIBRILLATION/TACHYCARDIA IN PATIENTS WITH PULMONARY HYPERTENSION: A MULTICENTRE RANDOMIZED TRIAL
Background: Atrial fibrillation (AF) and related atrial tachycardias (ATs) are common arrhythmias in patients with pulmonary hypertension (PH). The long-term...
ALVEOLAR MACROPHAGES DO NOT CONTRIBUTE TO THE DEVELOPMENT OF HYPOXIC PULMONARY HYPERTENSION BY CONTRIBUTING TO RADICAL TISSUE INJURY
We have shown previously that alveolar macrophages (AM) are involved in the development of hypoxic pulmonary hypertension (HPH). Since it...
A SINGLE CENTRE PROSPECTIVE STUDY COMPARING THE 0/1H AND 0/3H RULE OUT/RULE IN ALGORITHMS FOR MYOCARDIAL INFARCTION IN REAL CLINICAL PRACTICE OF UNIVERSITY HOSPITAL EMERGENCY DEPARTMENT
Background: High-sensitivity cardiac troponin (hs-cTn) is a key biomarker used in the assessment of patients presenting with chest pain. The...
COMPARISON OF ANGIOGRAPHIC EVALUATION AND HEMODYNAMIC MEASUREMENT OF THE SIGNIFICANCE OF NON INFARCT-RELATED RESIDUAL STENOSIS IN STEMI PATIENTS - SINGLE CENTER EXPERIENCE.
Introduction: Up to 50% of patients with STEMI have >50% stenosis in a major non-infarct related artery. Several studies have...
LONG-TERM CARDIOVASCULAR OUTCOME IN PATIENTS AFTER PPCI FOR STEMI. WHAT IS THE RISK PROFILE FOR CARDIOVASCULAR MORTALITY?
Background: Long-term cardiovascular mortality (CM) after primary percutaneous coronary intervention (pPCI) for ST-elevation myocardial infarction (STEMI) is poorly evaluated.Methods: Retrospective,...
COMPARISON OF SIX DECISION AID RULES FOR DIAGNOSIS OF ACUTE MYOCARDIAL INFARCTION IN ELDERLY PATIENTS PRESENTING TO THE EMERGENCY DEPARTMENT WITH ACUTE CHEST PAIN
Objective: This study aimed to evaluate the accuracy and effectiveness of different strategies for the diagnosis of acute myocardial infarction...
FAMILIAL HYPERCHOLESTEROLEMIA MUTATIONS IN CZECH POPULATION AND IN CZECH PATIENTS WITH ACUTE CORONARY SYNDROME
Introduction: Familial hypercholesterolemia (FH) is the most common monogenic disease associated with increased risk of atherosclerotic cardiovascular disease (ACVD). FH...
HYPERTRIGLYCERIDEMIC GENE SCORE IN PATIENTS WITH APOE2/E2 GENOTYPE AS A POSSIBLE PREDICTOR OF FAMILIAL DYSBETALIPOPROTEINEMIA
Introduction: Familial dysbetalipoproteinemia (FD) is an autosomal recessive (rarely dominant) inherited disorder that is almost exclusively associated with the apolipoprotein...
IN VITRO ASSESSMENT OF ANTI-INFLAMMATORY AND CYTOTOXICITY PROPERTIES OF COLCHICINE
Inflammation plays a substantial role in the process of atherosclerosis. The key players are monocytes transformed to macrophages and coronary...
EFFECT OF VENOARTERIAL EXTRACORPOREAL MEMBRANE OXYGENATION ON LEFT VENTRICULAR FUNCTION IN CARDIOGENIC SHOCK WITH AORTIC STENOSIS OR MITRAL REGURGITATION: AN EXPERIMENTAL STUDY IN PORCINE MODEL
Background: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is widely used in the treatment of cardiogenic shock (CS). However, increased VA-ECMO blood...
COMPARISON OF NEURON-SPECIFIC ENOLASE, TAU-PROTEIN AND NEUROFILAMENT LIGHT CHAIN VALUES FOR EARLY PROGNOSTICATION IN CARDIAC ARREST SURVIVORS
Introduction: Early prognostication in cardiac arrest survivors remains challenging despite multimodal approach. Currently, the only guidelines recommended biomarker for early prognostication is...
LACTATE IN REFRACTORY OUT-OF-HOSPITAL CARDIAC ARREST. THE PRAGUE OHCA STUDY SUBANALYSIS.
INTRODUCTION The prognosis of patients suffering refractory out-of-hospital cardiac arrest (OHCA) remains serious despite the implementation of extracorporeal cardiopulmonary resuscitation (ECPR)....
VENTRICULAR ARRHYTMIAS IN PATIENTS WITH IMPLANTED ICD: A POST HOC ANALYSIS OF PRAGUE OHCA TRIAL
Background Implantable cardioverter defibrillators (ICD) or cardiac resynchronization therapy (CRT-D) devices are routinely implanted as a secondary prevention of sudden cardiac...
GENDER DIFFERENCES AND SURVIVAL AFTER OUT OF HOSPITAL CARDIAC ARREST
Background: Published evidence regarding the effect of gender on outcome after out of hospital cardiac arrest (OHCA) is inconsistent. We aimed...
ABSENCE OF HEART RATE VARIABILITY CHANGE DURING FOLLOW UP AFTER COVID-19 DOESN’T SUGGEST DIRECT CARDIOVASCULAR IMPACT
Objective: To evaluate the need for cardiac monitoring of unselected patients recovered from COVID-19 and to estimate the risk of...
DETECTION OF ARRHYTHMIAS IN PATIENTS WITH CARDIAC AMYLOIDOSIS USING IMPLANTABLE ECG RECORDERS.
Introduction: Cardiac Amyloidosis frequently results in congestive cardiac failure and arrhythmias, from a disruption in cardiac substrate with subsequent electro-mechanical...
BIMODAL DISTRIBUTION OF QRS COMPLEX DURATION IN PATIENTS WITH DILATED CARDIOMYOPATHY UNDERGOING AN ICD IMPLANT PROCEDURE.
BackgroundIn patients with heart failure with reduced ejection fraction (HFrEF), QRS duration is of the uttermost importance. Substantial proportion of...
LEFT BUNDLE BRANCH PACING OF PROXIMAL LEFT BUNDLE BRANCH AND SEPTAL FASCICLE PRODUCES MORE PHYSIOLOGICAL ACTIVATION COMPARED TO PACING OF THE ANTERIOR FASCICLE
Background:Left bundle branch pacing is defined as the pacing of the trunk or its proximal fascicles. It is unknown, whether...
NITRIC OXIDE RELEASING PACING LEAD TO PREVENT INFECTION IN CARDIAC PACING
Background: Effective prevention of pacing lead infection could reduce morbidity and save lives. It has been demonstrated that nitric oxide...
DUCHENNE MUSCULAR DYSTROPHY: CARDIAC PHENOTYPE AS A RESULT OF DNA DAMAGE-INDUCED CHANGE OF STEM CELL FATE.
Duchenne muscular dystrophy (DMD) is caused by impaired dystrophin. Majority of the DMD patients suffer from cardiomyopathy, arrhythmias, and heart...
MYOCARDIAL INVOLVEMENT DETECTED USING CARDIAC MAGNETIC RESONANCE IMAGING IN PATIENTS WITH SYSTEMIC SCLEROSIS – A PROSPECTIVE OBSERVATIONAL STUDY
Introduction and objectives: Cardiac involvement in systemic sclerosis (SSc) patients affects mortality. Cardiac magnetic resonance (CMR) is capable of detecting...
ROLE OF MYOCARDIAL DEFORMATION ANALYZED BY 3D ECHOCARDIOGRAPHY IN FABRY DISEASE
Introduction: Fabry disease is a multisystemic lysosomal storage disorder caused by a defect in the gene coding the alpha-galactosidase A...
HEART FAILURE IN FABRY DISEASE REVISITED: APPLICATION OF CURRENT HEART FAILURE GUIDELINES AND RECOMMENDATIONS
Aims: Fabry disease (FD) is often associated with heart failure (HF). However, data on HF prevalence, prognosis, and applicability of...
NATION-WIDE SCREENING OF FABRY DISEASE IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY IN CZECH REPUBLIC (BY DRY BLOOD SPOT METHOD)
Aims: Fabry disease (FD) is a rare X-linked genetic disorder caused by -galactosidase A (AGALA) deficiency. While "classic" variant has...
PREDICTING LONG-TERM SURVIVAL AFTER AN ISCHEMIC STROKE
Background: To identify factors influencing long-term survival after ischemic stroke is of utmost importance. The aim of the present study...
TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND (TRAIL) IS ASSOCIATED WITH CARDIAC INJURY AND STROKE SEVERITY IN PATIENTS AFTER ACUTE ISCHEMIC STROKE
Stroke is accompanied by pathological disturbances leading to autonomic dysfunction and systemic inflammation. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is...
TRANSOESOPHAGEAL ECHOCARDIOGRAPHY FINDINGS IN YOUNG PATIENTS WITH CRYPTOGENIC ISCHEMIC STROKE
Background and purpose: The cause of ischemic stroke (IS) remains often unclear in young patients. Relevant structural heart abnormities with...
CATHETER THROMBECTOMY FOR ACUTE ISCHEMIC STROKE IN CARDIOLOGY CATH LAB: 10 YEARS RESULTS
Background and aim Acute ischemic stroke is a devastating disease with high mortality and frequent permanent severe functional disability. Catheter...
CHARACTERISTICS AND OUTCOMES OF PATIENTS ADMITTED FOR ACUTE HEART FAILURE IN A SINGLE CENTRE STUDY
Aims: Acute heart failure represents a medical condition with very high mortality. The aim of our study was to characterise...