THE HEMODYNAMIC EFFECTS OF SILVER NANOPARTICLES IN A SEPTIC PORCINE MODEL.

Introduction: Infectious diseases, which frequently lead to life-threatening sepsis and septic shock, represent a significant global health challenge. The pursuit of novel therapeutic strategies remains a primary focus of preclinical research.
Methodology:
This prospective experimental study, conducted using a porcine model, involved 39 pigs divided into six groups. The first group (n=6) served as the control group. The second group (n=6) received silver nanoparticle treatment. The third group (n=7) had bacteremia induced via continuous Klebsiella pneumoniae infusion. The fourth group (n=6) was subjected to bacteremia with concomitant administration of silver nanoparticles. The fifth group (n=6) received bacteremia induction followed by antibiotic treatment with piperacillin-tazobactam. The sixth group (n=8) received both bacteremia induction and treatment with silver nanoparticles in conjunction with antibiotics.
Results:
Heart rate showed a significant increase in the septic group, the group treated with silver nanoparticles, and the group treated with both silver nanoparticles and antibiotics. Mean pulmonary arterial pressure increased significantly across all groups by the conclusion of the experiment. Lactate levels were significantly elevated in the septic group treated with silver nanoparticles, as well as in the septic group treated with both silver nanoparticles and antibiotics. Fluid balance showed significant increases in the septic groups. Systemic vascular resistance was significantly reduced in the septic group and the group with sepsis treated with silver nanoparticles.
Conclusion: The application of silver nanoparticles, either alone or in combination with antibiotics, did not show any beneficial effects on hemodynamics of septic pigs and was not superior to the standard antibiotic therapy.