THERAPY OF ANGINA PECTORIS IN OUT-PATIENTS – PERSISTANCE OF INTERSEXUAL DIFFERENCES

Introduction: Pharmacological analysis from 90-ties demonstrated unapropriate structure of therapy of angina pectoris with preponderance of trinitrate therapy and deficiency in therapy of females. Females were less frequently treated by betablockers, antiaggregants and nitrates.
Method: Cross-sectional multicentre screening was performed by 228 general practitioners and cardiologists in 98 sites of Slovakia in 2006. Of 2945 enrolled patients with angina pectoris (aged 68.7± 9.9 yrs [36-91 yrs) were 41.9% males and 58.1% females.
Patients: Females were older (70.0±9.5 vs. 67.1 ±10.0; p<0.001) and more frequently obese (BMI≥30:  38.8% vs. 28.2%; p<0.05).  Males had more frequently arterial hypertension (64.6% vs. 35.6%; p<0.001), but prevalence of dyslipidemia (79.6% vs. 83.6%; NS) as well as of diabetes mellitus (47.5% vs. 54.8%; NS) were same.   Onset of angina pectoris was similar in both genders 59.3±14.2 vs. 61.2±15.3 yrs; (p=0.07; NS), however, initiation of AP therapy was delayed (2.0 vs 3.4 yrs; p<0.001). Consumption of short term nitrates was equal: 4.8±2.7 vs 5.1±3.3 tbl (NS). Structure of therapy is presented on Table.

Conclusion:  Significant intersexual differences in therapy of angina pectoris still persist. Betablocker therapy in females is less frequent and delayed more than one year. Molsidomine therapy is delayed more then three years as compare to male patietns.