RENAL FUNCTION AND LIPID SPECTRUM IN PATIENTS WITH ARTERIAL HYPERTENSION: COINCIDENCE OR CORRELATION?

Introduction: Causal relationship between blood pressure and renal function is well establish and accepted. However,  lipid spectrum level and markers of renal function in normal creatine level were not investigated in details in patients with arterial hypertension.
Method: Multicentral crosssectional project screened 1061 pts (M: 38.0%; F: 61.1%) with essential hypertention [(SBP: 156.1±13.4 vs. 152.2 ± 16.3 mm Hg (p<0.03); DBP (94.5±7.47 vs 92.9±8.3 mm Hg (p<0.003)]. All pts were analysed for lipid spectrum and creatinine (CREA) level). 36 pts were excluded  due to CREA> 135 μ mol/l.
Results:  After splitt of pts according to quartils[Q] of CREA, we found expected highest both SBP and DBP in the highest quartil of CREA (p<0.04; res. 0.02). Of lipid spectrum, only triacylglycerids exhibited significant increase with Q-CREA (p < 0.001) with correlation r = 0.17 (p<0.01). Waist circumference shown increase from 91.6±13.3 to 96.1±13.5 cm (p<0.03) in Q-CREA and it correlated both with Q-CREA[r = 0.12 (p<0.001)] and CREA [r = 0.13 (p<0.01)]. Adjustment to diabetes mellitus cancelled given correlations.
Conclusion: Significant association between serum creatine and triacylglycerids in pts with arterial hypertension could be caused by presence of diabetes mellitus and/or metabolic syndrom. Waist circumference shown significant direct relationship with increased creatinine.