MARKERS OF OXIDATIVE STRESS IN PATIENTS WITH ACUTE HEART FAILURE FOLLOWING ACUTE MYOCARDIAL INFARCTION

Purpose. Oxidative stress and persistent inflammation are implicated in the progression of heart failure. The aim of the study was to investigate selected parameters of oxidative stress (malondialdehyde, vitamins A and E and tumor necrosis factor-α) in patients with acute heart failure after acute myocardial infarction (AMI).
Methods. Venous blood samples from 237 patients in Prospect-AMI registry admitted consecutively to the coronary care unit (from 10/2005 to 10/2008) with AMI with ST-elevation were taken on admission and then after 24 hours, 1 month and 1 year from the onset of AMI. From the study were excluded non-collaborating patients, elderly patients over 80 years or patients with tumorous or any serious diseases predicting poor life prognosis.  All patients were with positive troponin I.
Results. Plasma values of vitamins were almost within reference interval. Levels of malondialdehyde and TNFα were elevated 18  and 46 % patients on admission, respectively. Level of malondialdehyde correlated positively with TNFα and vitamin A and level of TNFα correlated negatively with vitamin E on admission. In contrast to these correlations, there were no significant relationships between measured parameters and LV ejection fraction.
Conclusions. There were obtained levels of vitamins A and E and malondialdehyde. Only pro-inflammatory cytokine TNFα might provide some information in patients after AMI. Supported by grant MSM 0021622402 of the Ministry of Education of the Czech Republic.