WAIST IN METABOLIC SYNDROM: WHICH DEFINITION REFLECTS OXIDATIVE STRESS AT BEST?

Introduction: Metabolic syndrome (MS) is defined differently according to various definitions (WHO, EGIR, ATP III, Berlin modification 2005), including waist (W) circumference  defined by several cut points. MS is characterized by increased level of oxidative stress especially in females, however, predictive value different at-risk waist definitions has not been analysed. Method: 165 randomly selected females (63.2 ± 7.34 yrs)  with proved ischemic heart disease (IHD) and 60 controls (47.62 ± 9.68 yrs) were dichotomised according to 1. waist to hip ratio ≥ 0,90 (WH90);  2. W circumference ≥ 88 cm; 3. W circumference ≥ 80 cm;  We analysed risk ratio for increased level of oxidative stress markers:  oxidized glutahione (GSSG), Shiff base substance (SBS) (marker of lipoperoxidation); oxidized LDL (oxLDL); total antioxidative status (TAS), uric acid (UA), and carbonylated proteins (CP).

Results: See Picture

Conclusions: In female IHD-patients waist definition  appears to have the protected value only for the uric acid. In healthy females, we found waist circumference above 88 cm  as the definition of abdominal obesity for oxidative stress associated with metabolic syndrome.