CORRELATION OF NT-PROBNP WITH METABOLIC LIVER FUNCTION AS ASSESSED WITH 13C-METHACETIN BREATH TEST IN PATIENTS WITH ACUTE DECOMPENSATED HEART FAILURE | XIX. výroční sjezd České kardiologické společnosti

Přesná citace: Backround: Previous observations showed significant impairement of metabolic liver function as assessed with 13C-methacetin breath test in patients with advanced chronic heart failure. Purpose of the study: to evaluate correlation of NT-proBNP with metabolic liver function as assessed with 13C-methacetin breath test and other parameters involved in hepatic function in patients with acute decompensation of chronic heart failure (ADHF). Patients population and methods: NT-proBNP, 13C-methacetin breath test and other parameters, including: blood urea nitrogen (BUN), serum creatinin, serum bilirubin, ceruloplasmin, copper, total iron binding capacity (TIBC), were measured and realized in 13 consecutive ADHF patients with systolic LV dysfunction (EF ≤ 45%). The investigations were done twice: within 2 days and up to 7 days since hospital admission. Mean values of 1st (V1) and 2nd (V2) examinations were compared with t-test. Correlation of NT-proBNP with cumulative dose of 13CO2/CO2 in minutes 40 and 60 (CD40, CD60) and other parameters was assessed with Spearman´s correlation coeficient (r). Results: mean LV EF was 32,69%, mean NT-proBNP at V1 was 9781,31 pg/ml, mean CD40 9,57%, CD60 13,71%, bilirubin 19,21 µmol/l, copper 22,83 µmol/l, ceruloplasmin 0,33 g/l, and TIBC 60,92 µmol/l. Mean interval between V1 and V2 was 4.5 days. NT-proBNP and parameters of liver function CD40 and CD 60 didn´t significantly change between V1 and V2. Correlation of NT-proBNP and CD40, CD60 was not significant in both investigations. NT-proBNP correlated with BUN (r = 0,63, p = 0,020), creatinine (r = 0,55, p = 0,052) and serum ceruloplasmin (r = 0,73, p = 0,004) at V1. Metabolic liver function parameters CD40 and CD 60 correlated significantly with TIBC (inverse correlation r = - 0,68, p = 0,010 at V1, resp. r = - 0,69, p = 0,009 at V2). Conclusion: NT-proBNP and metabolic liver function as assessed with 13C-methacetin breath test didn´t change in first days after hospital admission in ADHF patients. Correlation of NT-proBNP with the degree of metabolic liver function impairement was not significant. The study revealed significant correlation of NT-proBNP with serum ceruloplasmin and significant inverse correlation of liver function with TIBC in patients with ADHF. The results of this pilot study should be confirmed in larger patients population. Approval of the study was granted by Local Board Ethics Committe EK/65/2005 and supported by Research Grant of the Czech Society of Cardiology 2006. Int J Cardiol 2010,144(2):321-322

PROHLÍŽENÍ ABSTRAKTA